N,N-dimethyldoxorubicin

Names

[ Name ]:
N,N-dimethyldoxorubicin

[Synonym ]:
(8S,10S)-10-((2R,4S,5S,6S)-4-Dimethylamino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-6,8,11-trihydroxy-8-(2-hydroxy-acetyl)-1-methoxy-7,8,9,10-tetrahydro-naphthacene-5,12-dione

Biological Activity

[Description]:

N,N-Dimethyldoxorubicin is a Doxorubicin (HY-15142A) analogue. N,N-Dimethyldoxorubicin shows cytotoxicity against a panel of tumor cell lines (IC50s < 0.3 μM)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Wander DPA, et al. Synthetic (N,N-Dimethyl)doxorubicin Glycosyl Diastereomers to Dissect Modes of Action of Anthracycline Anticancer Drugs. J Org Chem. 2021 Apr 16;86(8):5757-5770.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₃₃NO₁₁

[ Molecular Weight ]:
571.57200

[ Exact Mass ]:
571.20500

[ PSA ]:
183.29000

[ LogP ]:
0.60420

Related Compounds

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