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hypoxanthine-9-beta-d-arabinofuranoside

Names

[ CAS No. ]:
7013-16-3

[ Name ]:
hypoxanthine-9-beta-d-arabinofuranoside

[Synonym ]:
Ara-H
Ara-I
9-(b-D-Arabinofuranosyl)hypoxanthine
hypoxanthine arabinoside
Arabinosylhypoxanthine
ARABINOFURANOSYL-HYPOXANTHINE
9-pentofuranosyl-1,9-dihydro-purin-6-one

Biological Activity

[Description]:

Arabinosylhypoxanthine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
2.08g/cm3

[ Boiling Point ]:
732.8ºC at 760 mmHg

[ Melting Point ]:
259-260 °C (lit.)

[ Molecular Formula ]:
C10H12N4O5

[ Molecular Weight ]:
268.23

[ Flash Point ]:
397ºC

[ Exact Mass ]:
268.08100

[ PSA ]:
133.75000

[ Index of Refraction ]:
1.879

[ Storage condition ]:
−20°C

Safety Information

[ Hazard Codes ]:
Xn

[ Safety Phrases ]:
24/25

[ WGK Germany ]:
3

Related Compounds