1-(4-Hydroxyphenyl)propan-1-one
Names
[ CAS No. ]:
70-70-2
[ Name ]:
1-(4-Hydroxyphenyl)propan-1-one
[Synonym ]:
4'-hydroxy-propiophenone
H-365
EINECS 202-815-9
paroxypropione
p-Hydroxypropiophenone
1-Propanone, 1-(4-hydroxyphenyl)-
4-Hydroxypropiophenone
Mepal
POP
para-hydroxy-propiophenone
1-(4-hydroxyphenyl)propan-1-one
MFCD00008745
Hypostat
p-HOC6H4COEt
PHP
1-(4-Hydroxyphenyl)-1-propanone
Paroxon
Bio-Fren
Frenon
B 360
VANATONE
Biological Activity
[Description]:
[Related Catalog]:
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
152-154 °C26 mm Hg(lit.)
[ Melting Point ]:
36-38 °C(lit.)
[ Molecular Formula ]:
C9H10O2
[ Molecular Weight ]:
150.174
[ Flash Point ]:
>230 °F
[ Exact Mass ]:
150.068085
[ PSA ]:
37.30000
[ LogP ]:
1.96
[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.542
[ Water Solubility ]:
0.34 g/l (15 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UH1925000
- CHEMICAL NAME :
- Propiophenone, 4'-hydroxy-
- CAS REGISTRY NUMBER :
- 70-70-2
- BEILSTEIN REFERENCE NO. :
- 0907511
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C9-H10-O2
- MOLECULAR WEIGHT :
- 150.19
- WISWESSER LINE NOTATION :
- QR DV2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,29,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1130 ug/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 124,212,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Amphibian - frog
- DOSE/DURATION :
- 91 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 124,212,1960 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 1600 mg/kg
- SEX/DURATION :
- female 15-30 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Effects on Newborn - stillbirth
- REFERENCE :
- AOGNAX Archivio di Ostetricia e Ginecologia. (C.C. Postale N 6/19773, Naples, Italy) V.1- 1894- Volume(issue)/page/year: 66,286,1961
Safety Information
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn;Xi
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S37-S24/25-S36-S26
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
UH1925000
[ HS Code ]:
29145000
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2914501900
[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
Articles
Bioorg. Med. Chem. 17 , 896-904, (2009)
This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret...
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.Toxicol. Mech. Methods 18 , 217-27, (2008)
ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifes...
Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives.Bioorg. Med. Chem. Lett. 16 , 592-5, (2006)
4-Hydroxybenzaldehyde (HBA) derivatives were examined as inhibitors for GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH). Investigation of structure-activity relation reveale...