2-Methyl-4-nitroimidazole
Names
[ CAS No. ]:
696-23-1
[ Name ]:
2-Methyl-4-nitroimidazole
[Synonym ]:
2-Methyl-4-nitro-1H-imidazole
EINECS 211-790-3
MFCD00005191
2-Methyl-4-nitroimidazole
Metronidazole Impurity 1
Chemical & Physical Properties
[ Density]:
1.426g/cm3
[ Boiling Point ]:
399.5ºC at 760 mmHg
[ Melting Point ]:
251-255ºC(lit.)
[ Molecular Formula ]:
C4H5N3O2
[ Molecular Weight ]:
127.10100
[ Flash Point ]:
195.4ºC
[ Exact Mass ]:
127.03800
[ PSA ]:
74.50000
[ LogP ]:
1.14950
[ Index of Refraction ]:
1.591
[ Storage condition ]:
Refrigerator
[ Stability ]:
Stable. Incompatible with strong oxidizing agents.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NI7550000
- CHEMICAL NAME :
- Imidazole, 2-methyl-5-nitro-
- CAS REGISTRY NUMBER :
- 696-23-1
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C4-H5-N3-O2
- MOLECULAR WEIGHT :
- 127.12
- WISWESSER LINE NOTATION :
- T5M CNJ B1 ENW
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Klebsiella pneumoniae
- DOSE/DURATION :
- 5 mmol/L/20H
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 66,207,1979
Safety Information
[ Symbol ]:
GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H351
[ Precautionary Statements ]:
P281
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
S22-S36/37
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
NI7550000
[ HS Code ]:
2933290090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933290090
[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
J. Pharm. Sci. 92(4) , 739-46, (2003)
Using two UV-spectrophotometric methods, the hydrolysis of tinidazole was studied at pH 1.00-8.45 at 80 degrees C. The reaction followed apparent first-order kinetics throughout the studied range. No ...
Radicals of nitroimidazole derivatives: pH dependence of rates of formation and decay related to acid-base equilibria.Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 51(5) , 797-809, (1987)
Three analogous 5-nitroimidazoles, having radiosensitizing and cytotoxic properties, have been studied by pulse-radiolysis in N2O-saturated aqueous formate solutions. Rates of formation of the radical...
[Synthesis and antibacterial activity of ciprofloxacin derivatives].Yao Xue Xue Bao 40(2) , 132-5, (2005)
To study the synthesis and antibacterial activity of ciprofloxacin derivatives.Ciprofloxacin derivatives were synthesized primarily from 2-methyl-5-nitroimidazol and ciprofloxacin through nucleophilic...