5-Iodouracil

Names

[ CAS No. ]:
696-07-1

[ Name ]:
5-Iodouracil

[Synonym ]:
5-iodopyriMidine-2.4-diol
EINECS 211-788-2
5IU
2,4(1H,3H)-Pyrimidinedione, 5-iodo-
5-iodopyrimidine-2,4-diol
5-Iodo-2,4(1H,3H)-pyrimidinedione
5-IODOURACIL extrapure
5-iodine uracil
5-iodopyrimidine-2,4(1H,3H)-dione
5-iodo-2,4-dioxopyrimidine
4-iodouracil
5-Iodpyrimidin-2,4(1H,3H)-dion
MFCD00006020
5-Iodouracil
2(1H)-pyrimidinone, 4-hydroxy-5-iodo-
5-iodo-uraci
5-iodo uracil

Chemical & Physical Properties

[ Density]:
2.4±0.1 g/cm3

[ Boiling Point ]:
401ºC

[ Melting Point ]:
274-276 °C (dec.)(lit.)

[ Molecular Formula ]:
C₄H₃IN₂O₂

[ Molecular Weight ]:
237.983

[ Exact Mass ]:
237.923904

[ PSA ]:
66.24000

[ LogP ]:
0.14

[ Index of Refraction ]:
1.706

[ Storage condition ]:
0-6°C

[ Water Solubility ]:
SOLUBLE IN COLD WATER

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YR0525000

CHEMICAL NAME :: Uracil, 5-iodo-

CAS REGISTRY NUMBER :: 696-07-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C4-H3-I-N2-O2

MOLECULAR WEIGHT :: 237.99

WISWESSER LINE NOTATION :: T6MVMVJ FI

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 13,1249,1964

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R46;R20/21/22;R36/37/38

[ Safety Phrases ]:
S53-S22-S26-S36/37/39-S45

[ RIDADR ]:
2811

[ WGK Germany ]:
3

[ RTECS ]:
YR0525000

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Enzymatic primer-extension with glycerol-nucleoside triphosphates on DNA templates.

PLoS ONE 4(3) , e4949, (2009)

Glycerol nucleic acid (GNA) has an acyclic phosphoglycerol backbone repeat-unit, but forms stable duplexes based on Watson-Crick base-pairing. Because of its structural simplicity, GNA is of particula...

Highly hydrophilic and nonionic poly(2-vinyloxazoline)-grafted silica: a novel organic phase for high-selectivity hydrophilic interaction chromatography.

Anal. Bioanal. Chem 406(19) , 4585-93, (2014)

A new hydrophilic and nonionic poly(2-vinyloxazoline)-grafted silica (Sil-VOX(n)) phase was synthesized and applied for the separation of nucleosides and nucleobases in hydrophilic interaction chromat...

Preparation and properties of oligodeoxynucleotides containing 5-iodouracil and 5-bromo- and 5-iodocytosine.

Bioconjug. Chem. 8(5) , 757-61, (1997)

The behavior of oligonucleotides containing 5-iodouracil, 5-bromocytidine, and 5-iodocytidine in concentrated ammonia is described. 5-Aminouracil and 5-aminocytidine are obtained as side products when...