3-Chloromethylpyridinehydrochloride
Names
[ CAS No. ]:
6959-48-4
[ Name ]:
3-Chloromethylpyridinehydrochloride
[Synonym ]:
3-Chloromethylpyridinehydrochloride
3-(Chloromethyl)pyridine hydrochloride (1:1)
EINECS 230-150-4
3-Chloromethylpyridine hydrochloride
Pyridine, 3- (chloromethyl)-, hydrochloride
Pyridine, 3-(chloromethyl)-, hydrochloride (1:1)
3-(chloromethyl)pyridine,hydrochloride
MFCD00012818
3-(Chloromethyl)pyridine, hydrochloride
Chemical & Physical Properties
[ Boiling Point ]:
210ºC at 760 mmHg
[ Melting Point ]:
137-143 °C(lit.)
[ Molecular Formula ]:
C6H7Cl2N
[ Molecular Weight ]:
164.033
[ Flash Point ]:
62ºC
[ Exact Mass ]:
162.995560
[ PSA ]:
12.89000
[ LogP ]:
2.62240
[ Water Solubility ]:
>=10 g/100 mL at 19 ºC
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- US7000000
- CHEMICAL NAME :
- Pyridine, 3-chloromethyl-, hydrochloride
- CAS REGISTRY NUMBER :
- 6959-48-4
- LAST UPDATED :
- 199506
- DATA ITEMS CITED :
- 16
- MOLECULAR FORMULA :
- C6-H6-Cl-N.Cl-H
- MOLECULAR WEIGHT :
- 164.04
- WISWESSER LINE NOTATION :
- T6NJ C1G &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 316 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 316 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 37 gm/kg/83W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 49 gm/kg/81W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Tumorigenic - tumors at site of application
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - mouse Lymphocyte
- DOSE/DURATION :
- 5 mg/L
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 9,143,1987
Safety Information
[ Symbol ]:
GHS05, GHS07
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H302-H314
[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R22;R36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
2811
[ WGK Germany ]:
3
[ RTECS ]:
US7000000
[ Packaging Group ]:
III
[ Hazard Class ]:
8
[ HS Code ]:
29333999
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933399090
[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Environ. Mutagen. 9(2) , 143-60, (1987)
Nine substances were tested for their mutagenic potential in the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay, by means of procedures based upon those described by Clive and Spector (Muta...
Assays of three carcinogen/non-carcinogen chemical pairs for in vivo induction of chromosome aberrations, sister chromatid exchanges and micronuclei.Environ. Mol. Mutagen. 14(4) , 207-20, (1989)
Three pairs of structurally similar carcinogenic/non-carcinogenic chemicals were tested for in vivo genotoxic activity in B6C3F1 mice. The carcinogenic/non-carcinogenic pairs, respectively, were o-tol...