Nicotinyl alcohol

Names

[ CAS No. ]:
100-55-0

[ Name ]:
Nicotinyl alcohol

[Synonym ]:
(Pyridin-3-yl)methanol
3-Pyridylmethanol
pyridylcarbinol
pyridin-3-ylmethanol
3-Pyridinylmethanol
b-Pyridinecarbinol
3-PYRIDINYLCARBINOL
3-hydroxymethylpyridine
β-Pyridinecarbinol
3-Pyridinemethanol
pyridine, 3-(hydroxymethyl)-
3-(Hydroxymethyl)pyridine
EINECS 202-864-6
Nicotinyl alcohol
β-Picolyl alcohol
Pyridylmethanol
MFCD00006407
RO 1-5155
b-Pyridylcarbinol
β-Pyridylcarbinol
b-Picolyl Alcohol

Biological Activity

[Description]:

3-Pyridinemethanol (Nicotinyl alcohol), a pyridine derivative, is a cholesterol-lowering agent[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Heiberg A. Nikotinyl-alkohol som kolesterolsenkende medikament [Nicotinyl alcohol as a cholesterol-lowering agent]. Nord Med. 1969;81(22):698-700.

[2]. Gargaun S, et al. A novel method aimed at counteracting the side effects caused by prostaglandin e2 deficiency during non-steroidal anti-inflammatory drug therapy. Antiinflamm Antiallergy Agents Med Chem. 2014;13(2):121-127.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
266.0±0.0 °C at 760 mmHg

[ Melting Point ]:
-7 °C

[ Molecular Formula ]:
C₆H₇NO

[ Molecular Weight ]:
109.126

[ Flash Point ]:
97.5±20.4 °C

[ Exact Mass ]:
109.052765

[ PSA ]:
33.12000

[ LogP ]:
-0.46

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.551

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT4690000

CHEMICAL NAME :: 3-Pyridinemethanol

CAS REGISTRY NUMBER :: 100-55-0

BEILSTEIN REFERENCE NO. :: 0107851

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H7-N-O

MOLECULAR WEIGHT :: 109.14

WISWESSER LINE NOTATION :: T6NJ C1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 11,242,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 22,483,1962

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/38

[ Safety Phrases ]:
S26-S36-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UT4690000

[ HS Code ]:
29333999

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Inhibitory effects of niacin and its analogues on induction of ornithine decarboxylase activity by diethylnitrosamine in rat liver.

Biochem. Pharmacol. 36(18) , 3015-9, (1987)

Pharmacological doses of niacin and its analogues were given intraperitoneally to rats with and without coadministration of a hepatocarcinogenic dose of diethylnitrosamine (DEN), and their effects on ...

The role of p53 in the cellular toxicity by active trans-platinum complexes containing isopropylamine and hydroxymethylpyridine.

Eur. J. Med. Chem. 45(1) , 134-41, (2010)

Despite some initial research that reported a lack of activity of trans geometry, complexes with general formula trans-[PtCl2(L)(L')] exhibit an important cytotoxic activity in cisplatin-sensitive and...

Oxidation of alcohols using a manganese (II) complex based on a pentakis benzimidazole amide ligand.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 74(2) , 536-43, (2009)

A pentakis benzimidazole based penta-amide ligand diethylenetriamine-N,N,N',N',N''-pentakis(2-methyl benzimidazolyl)penta-amide [GBDTPA] has been synthesized and utilized to prepare Mn (II) complexes ...