Pendulone
Names
[ CAS No. ]:
69359-09-7
[ Name ]:
Pendulone
Biological Activity
[Description]:
Pendulone is a isoflavanquinone with good antiplasmodial activity with an IC50 of 7.0 µM. Pendulone also has antileishmanial, antibacterial and anticancer activity[1][2].
[Related Catalog]:
[In Vitro]
Pendulone displays moderate antiproliferative activity against the A2780 human ovarian cancer cell line, with an IC50 value 19.6 µM[1]. Pendulone displays an IC50 value of 0.43 µg/mL, against L. donovani promastigotes. Pendulone also displays antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus (each IC50 of 1.44 µg/mL)[2]. Pendulone exhibits moderate anticancer activity against human cancer cell lines (SK-MEL, KB, BT-549 and SK-OV-3) with IC50 values of 5.5 and 10.5 μg/mL. Pendulone also shows moderate cytotoxicities against monkey kidney fibroblasts (VERO) and pig kidney epithelial cells (LLC-PK11)[2]. Pendulone shows strong inhibition on the effect of the cell cycle induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in Raji cells[3].
[In Vivo]
Pendulone shows potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test of mouse skin using 7,12-dimethylbenz[a]-anthracene and TPA[3].
[References]
Chemical & Physical Properties
[ Boiling Point ]:
546.8±50.0 °C(Predicted)
[ Melting Point ]:
221-223 °C
[ Molecular Formula ]:
C17H16O6
[ Molecular Weight ]:
316.30534
Safety Information
[ Hazard Codes ]:
Xi