EG1

Names

[ Name ]:
EG1

[Synonym ]:
2-({4-[(2-Methoxybenzoyl)amino]benzoyl}amino)benzoic acid
Benzoic acid, 2-[[4-[(2-methoxybenzoyl)amino]benzoyl]amino]-

Biological Activity

[Description]:

Pax2 inhibitor EG1 (EG1) is a potent, small molecule inhibitor of Pax2 mediated transcription activation, effectively blocks Pax2 activity and DNA binding with Kd of 1.35-1.5 uM; inhibits Pax2 mediated expression with IC50 of 10 uM, and inhibits proliferation of Pax2 positive renal and ovarian cancer cell lines but has little effect on Pax2 negative cancer cells; inhibits embryonic kidney development.

[References]

References 1. Grimley E, et al. ACS Chem Biol. 2017 Mar 17;12(3):724-734. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
490.9±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₁₈N₂O₅

[ Molecular Weight ]:
390.389

[ Flash Point ]:
250.7±27.3 °C

[ Exact Mass ]:
390.121582

[ LogP ]:
3.98

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.695

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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