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3-O-cis-p-Coumaroylmaslinic acid

Names

[ CAS No. ]:
69297-40-1

[ Name ]:
3-O-cis-p-Coumaroylmaslinic acid

[Synonym ]:
Olean-12-en-28-oic acid, 2-hydroxy-3-[[(2Z)-3-(4-hydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-, (2α,3β)-
(2α,3β)-2-Hydroxy-3-{[(2Z)-3-(4-hydroxyphenyl)-2-propenoyl]oxy}olean-12-en-28-oic acid

Biological Activity

[Description]:

3-O-cis-p-Coumaroyl maslinic acid (compound 16) is a natural compound isolated from the ethyl acetate extract of leaves of Miconia albicans.3-O-cis-p-Coumaroyl maslinic acid can inhibit PTP1B, with the IC50 of 0.46 μM, and shows antimicrobial activity on Gram-positive bacteria and yeasts[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
Research Areas >> Infection
Research Areas >> Metabolic Disease
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

0.46 μM (PTP1B)[1]


[References]

[1]. de Cássia Lemos Lima R, et al. High-Resolution PTP1B Inhibition Profiling Combined with HPLC-HRMS-SPE-NMR for Identification of PTP1B Inhibitors from Miconia albicans. Molecules. 2018;23(7):1755.  

[2]. Braca A, et al. Antimicrobial triterpenoids from Licania heteromorpha. Planta Med. 2000;66(8):768-769.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
715.6±60.0 °C at 760 mmHg

[ Melting Point ]:
278-282 °C

[ Molecular Formula ]:
C39H54O6

[ Molecular Weight ]:
618.843

[ Flash Point ]:
214.5±26.4 °C

[ Exact Mass ]:
618.392029

[ LogP ]:
9.85

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.597

Related Compounds