6-Maleimidocaproic acid-PFP ester

Names

[ Name ]:
6-Maleimidocaproic acid-PFP ester

[Synonym ]:
6-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-hexanoic acid pentafluorophenyl ester
6-maleimidohexanoic acid pentafluorophenyl ester
pentafluorophenyl 6-maleimidohexanoate

Biological Activity

[Description]:

6-Maleimidocaproic acid-PFP ester is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₂F₅NO₄

[ Molecular Weight ]:
377.26300

[ Exact Mass ]:
377.06900

[ PSA ]:
63.68000

[ LogP ]:
2.71080

Related Compounds

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