Imidazole-d4

Names

[ Name ]:
Imidazole-d4

[Synonym ]:
MFCD00082554
fully deuterated imidazole
imidazole-2,4,5-d3
1H-Imidazole-1,2,4,5-d4
Imidazole-d4
1,2,4,5-deuterated imidazole
imidazole D1245
1,2,4,5-tetradeutero-imidazole

Biological Activity

[Description]:

Imidazole-d4 is the deuterium labeled Imidazole[1].

[Related Catalog]:

Research Areas >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Chemical & Physical Properties

[ Density]:
1.182g/cm3

[ Boiling Point ]:
257ºC at 760 mmHg

[ Melting Point ]:
89-91ºC

[ Molecular Formula ]:
C₃D₄N₂

[ Molecular Weight ]:
72.10190

[ Flash Point ]:
145ºC

[ Exact Mass ]:
72.06260

[ PSA ]:
28.68000

[ LogP ]:
0.40970

[ Index of Refraction ]:
1.528

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H314-H360D

[ Precautionary Statements ]:
P201-P280-P305 + P351 + P338-P310

[ Hazard Codes ]:
C

[ Risk Phrases ]:
22-34

[ Safety Phrases ]:
22-26-36/37/39-45

[ RIDADR ]:
UN 3259 8/PG 2

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Far-Infrared Spectra and Hydrogen-Bond Frequencies of Imidazole. Perchard C and Novak A.

J. Chem. Phys. 48(7) , 3079-3084, (1968)

Synthesis of the perdeuterated cellulose solvents 1-ethyl-3-methylimidazolium acetate (EMIM-OAc-d₁₄) and 1-butyl-3-methylimidazolium acetate (BMIM-OAc-d₁₈) and of 2-¹³C-butyl-3-methylimidazolium acetate. Yoneda Y, et al.

J. Labelled Comp. Radiopharm. 52(6) , 223-226, (2009)

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.