Luteolin-4'-O-glucoside

Names

[ Name ]:
Luteolin-4'-O-glucoside

[Synonym ]:
luteolin-4'-glucoside
3',4',5,7-tetrahydroxyflavone-4'-glucoside
MFCD00017468

Biological Activity

[Description]:

Luteolin-4'-O-glucoside is an IL-5 inhibitor with an IC50 of 3.7 μM. Luteolin-4'-O-glucoside resists hyperuricemia and acute gouty arthritis activity. Luteolin-4'-O-glucoside shows anticancer activity[1][2][3].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related

Research Areas >> Inflammation/Immunology

[Target]

IC50: 3.7 μM (IL-5)[1]

[In Vitro]

Luteolin-4'-O-glucoside shows cytotoxic activity against NCI-H929, U266, and OPM2 cell lines[3].

[References]

[1]. Park KY, et al. Inhibitory effect of luteolin 4'-O-glucoside from Kummerowia striata and other flavonoids on interleukin-5 bioactivity. Planta Med. 1999 Jun;65(5):457-9.

[2]. Lin Y, et al. Luteolin-4'-O-glucoside and its aglycone, two major flavones of Gnaphalium affine D. Don, resist hyperuricemia and acute gouty arthritis activity in animal models. Phytomedicine. 2018 Mar 1;41:54-61.

[3]. Xu T, et al. Glycosylation of luteolin in hydrophilic organic solvents and structure–antioxidant relationships of luteolin glycosides. RSC Advances, 2022, 12(28): 18232-18237.

Chemical & Physical Properties

[ Density]:
1.713g/cm3

[ Boiling Point ]:
814.5ºC at 760 mmHg

[ Melting Point ]:
210ºC (dec.)

[ Molecular Formula ]:
C₂₁H₂₀O₁₁

[ Molecular Weight ]:
448.37700

[ Flash Point ]:
288.5ºC

[ Exact Mass ]:
448.10100

[ PSA ]:
190.28000

[ Index of Refraction ]:
1.74

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Related Compounds

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