DTNB

Names

[ CAS No. ]:
69-78-3

[ Name ]:
DTNB

[Synonym ]:
3-Carboxy-4-nitrophenyl disulfide
EINECS 200-714-4
3,3'-Disulfanediylbis(6-nitrobenzoic acid)
Benzoic acid, 3,3'-dithiobis[6-nitro-
Ellman Reagent
MFCD00007140
5,5'-dithiobis-(2-nitrobenzoic acid)
5,5'-DITHIOBIS(2-NITROBENZOIC ACID)
5,5'-Dithobis(2-Nitrobenzoic Acid)
5,5-Dithiobis(2-nitrobenzoic acid)
5,5′-Dithiobis(2-nitrobenzoic acid)
UNII:9BZQ3U62JX
DTNB

Biological Activity

[Description]:

DTNB(Ellman’s Reag) is a chemical used to quantify the number or concentration of thiol groups in a sample; can be used for measuring low-molecular mass thiols such as glutathione in both pure solutions and biological samples, such as blood.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Biochemical Assay Reagents

Research Areas >> Others

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
671.9±55.0 °C at 760 mmHg

[ Melting Point ]:
240-245 °C (dec.)(lit.)

[ Molecular Formula ]:
C₁₄H₈N₂O₈S₂

[ Molecular Weight ]:
396.352

[ Flash Point ]:
360.1±31.5 °C

[ Exact Mass ]:
395.972198

[ PSA ]:
216.84000

[ LogP ]:
3.97

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.769

[ Storage condition ]:
Store at RT.

[ Stability ]:
Stable. Incompatible with strong bases, strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG9650000

CHEMICAL NAME :: Benzoic acid, 3,3'-dithiobis(6-nitro-

CAS REGISTRY NUMBER :: 69-78-3

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C14-H8-N2-O8-S2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2080 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,284,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7018 No. of Facilities: 23 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 197 (estimated) No. of Female Employees: 145 (estimated)

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DG9650000

[ HS Code ]:
29309070

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Disturbed Hsp70 and Hsp27 expression and thiol redox status in porcine kidney PK15 cells provoked by individual and combined ochratoxin A and citrinin treatments.

Food Chem. Toxicol. 71 , 97-105, (2014)

The aim of this study was to explore the oxidative properties of ochratoxin A (OTA) and citrinin (CTN) as a possible underlying mechanism of their individual and/or combined cytotoxicity. Metabolic ac...

Metabolic and tissue-specific regulation of acyl-CoA metabolism.

PLoS ONE 10(3) , e0116587, (2015)

Acyl-CoA formation initiates cellular fatty acid metabolism. Acyl-CoAs are generated by the ligation of a fatty acid to Coenzyme A mediated by a large family of acyl-CoA synthetases (ACS). Conversely,...

Mitochondrial NADP(+)-dependent isocitrate dehydrogenase knockdown inhibits tumorigenicity of melanoma cells.

Biochem. Biophys. Res. Commun. 451(2) , 246-51, (2014)

The potent cytotoxicity of reactive oxygen species (ROS) can cause various diseases but may also serve as a powerful weapon capable of destroying cancer cells. Although the balance between generation ...