IWP 12

Names

[ Name ]:
IWP 12

[Synonym ]:
2-[(3,6-Dimethyl-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide
Acetamide, N-(6-methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3,6-dimethyl-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-
IWP-12

Biological Activity

[Description]:

IWP-12 is a potent inhibitor of porcupine (PORCN) and inhibits cell-autonomous Wnt signaling with an IC50 of 15 nM[1].

[Related Catalog]:

Research Areas >> Others

[References]

[1]. Wang X, et al. The development of highly potent inhibitors for porcupine. J Med Chem. 2013 Mar 28;56(6):2700-4.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C₁₈H₁₈N₄O₂S₃

[ Molecular Weight ]:
418.556

[ Exact Mass ]:
418.059174

[ LogP ]:
3.99

[ Index of Refraction ]:
1.783

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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