Arborine

Names

[ Name ]:
Arborine

[Synonym ]:
Glycosine
2-benzyl-1-methyl-1H-quinazolin-4-one
2-Benzyl-1-methyl-4(1H)-quinazolinone
1-Methyl-2-benzyl-chinazol-4-on = Arborin
Glycosin
1-Methyl-2-benzyl-4(1H)-chinazolinon (Arborin)
Arborin
2-BENZYL-1-METHYL-QUINAZOLIN-4-ONE
2-Benzyl-1-methylquinazolin-4(1H)-one
Arborine
1-Methyl-2-benzyl-chinazolon-(4)
2-Benzyl-1-methyl-1H-chinazolin-4-on
1-Methyl-2-(phenylmethyl)-4(1H)-quinazolinone
2-Benzyl-1-methylquinazol-4-one
4(1H)-Quinazolinone, 1-methyl-2-(phenylmethyl)-

Biological Activity

[Description]:

Arborine, isolated from Glycosmis arborea, inhibits the peripheral action of acetylcholine and induces a fall in blood pressure[1][1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> mAChR

[References]

[1]. Michael JP. Quinoline, quinazoline and acridone alkaloids. Nat Prod Rep. 2003 Oct;20(5):476-93.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
421.0±38.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₄N₂O

[ Molecular Weight ]:
250.295

[ Flash Point ]:
208.4±26.8 °C

[ Exact Mass ]:
250.110611

[ PSA ]:
34.89000

[ LogP ]:
2.25

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.622

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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