Phellodendrine

Names

[ Name ]:
Phellodendrine

[Synonym ]:
OB-5 Compound
Phellodendrin
2,11-dihydroxy-3,10-dimethoxy-7-methyl-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinolinium
6H-Dibenzo(a,g)quinolizinium,5,8,13,13a-tetrahydro-2,11-dihydroxy-3,10-dimethoxy-7-methyl-,(7S-cis)
6H-Dibenzo[a,g]quinolizinium, 5,8,13,13a-tetrahydro-2,11-dihydroxy-3,10-dimethoxy-7-methyl-, chloride, (13aS)- (1:1)
Phallodendrin
Phellodendrine
(13aS)-2,11-Dihydroxy-3,10-dimethoxy-7-methyl-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinolinium chloride

Biological Activity

[Description]:

Phellodendrine, a isoquinoline alkaloid, is one of important characteristic ingredients in the Phellodendri chinensis cortex. phellodendrine is against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway. Phellodendrine has good antioxidant, and anti-inflammatory effect [1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[Target]

Akt

NF-κB

[References]

[1]. Li L , et al. The defensive effect of phellodendrine against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway in zebrafish embryos. Life Sci. 2016 Jul 15;157:97-106.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₄NO₄

[ Molecular Weight ]:
377.862

[ Exact Mass ]:
377.139374

[ PSA ]:
58.92000

[ LogP ]:
2.87390

Related Compounds

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