BC-11-38

Names

[ Name ]:
BC-11-38

[Synonym ]:
bc 11-38

Biological Activity

[Description]:

BC11-38 is a potent, selective, and biologically active PDE11 inhibitor, with IC50s of 0.28 µM and >100 µM for PDE11 and PDE1-10, respectively. BC11-38 elevates cAMP levels, PKA-mediated ATF-1 phosphorylation, and cortisol production in H295R cells[1].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

[Target]

PDE11:0.28 μM (IC50)

[In Vitro]

BC11-38 (20 μM; hours) elevate cAMP levels in H295R adrenocortical cells[1].

[References]

[1]. Ceyhan O, et al. Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen. Chem Biol. 2012;19(1):155-163.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₆N₂OS₂

[ Molecular Weight ]:
304.43000

[ Exact Mass ]:
304.07000

[ PSA ]:
85.49000

[ LogP ]:
3.38280

Related Compounds

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