HS 38

Names

[ Name ]:
HS 38

[Synonym ]:
2-{[1-(3-Chlorophenyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl}propanamide
Propanamide, 2-[[1-(3-chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]-

Biological Activity

[Description]:

HS-38 is a potent and selective DAPK1 and DAPK3 (ZIPK) inhibitor with IC50 of 200 nM for DAPK1 and Kd of 280 nM for ZIPK, also inhibits Pim3 (IC50=200 nM), and displays no activity against Src or Abl, little activity against EGFR; decreases RLC20 phosphorylation in cells, and decreases contractile force generated in mouse aorta, rabbit ileum, and calyculin A stimulated arterial muscle by decreasing RLC20 and MYPT1 phosphorylation; also promotes relaxation in Ca(2+)-sensitized vessels.

[References]

References 1. Carlson DA, et al. ACS Chem Biol. 2013 Dec 20;8(12):2715-23. 2. MacDonald JA, et al. Mol Pharmacol. 2016 Jan;89(1):105-17. View Related Products by Target DAPK

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Molecular Formula ]:
C₁₄H₁₂ClN₅O₂S

[ Molecular Weight ]:
349.795

[ Exact Mass ]:
349.040009

[ LogP ]:
1.27

[ Index of Refraction ]:
1.775

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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