NB 001

Names

[ Name ]:
NB 001

[Synonym ]:
nb001
unii-j89qt81nbq
5-{[2-(6-amino-9h-purin-9-yl)ethyl]amino}-1-pentanol
NB 001

Biological Activity

[Description]:

NB001 (HTS 09836) is an adenylcyclase 1 (AC1) inhibitor which has effect on neural and non-neural pain by modulating AC1 activity[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adenylate Cyclase

Research Areas >> Neurological Disease

[Target]

AC1[1]

[References]

[1]. Min Zhuo. Method for treating neuronal and non-neuronal pain. US8124599B2.

Chemical & Physical Properties

[ Density]:
1.37 g/cm3

[ Boiling Point ]:
521.3ºC at 760 mmHg

[ Melting Point ]:
146-148ºC

[ Molecular Formula ]:
C₁₂H₂₀N₆O

[ Molecular Weight ]:
264.32700

[ Flash Point ]:
269.1ºC

[ Exact Mass ]:
264.17000

[ PSA ]:
101.88000

[ LogP ]:
1.13280

[ Storage condition ]:
-20 °C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ RIDADR ]:
UN 2811 6.1 / PGIII

Articles

Estradiol modulates translocator protein (TSPO) and steroid acute regulatory protein (StAR) via protein kinase A (PKA) signaling in hypothalamic astrocytes.

Endocrinology 155(8) , 2976-85, (2014)

The ability of the central nervous system to synthesize steroid hormones has wide-ranging implications for physiology and pathology. Among the proposed roles of neurosteroids is the regulation of the ...