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RR-11a analog

Names

[ CAS No. ]:
685543-66-2

[ Name ]:
RR-11a analog

Biological Activity

[Description]:

RR-11a analog is a potent and selective inhibitors of asparaginyl endopeptidases (AE) (Legumain), with IC50 values of 4.5 nM, 4.5 nM and 31 nM for AE1 in Trichomonas Vaginalis, AE in Ixodes ricinus and AE in Schistosoma mansoni, respectively[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Others >> Others

[Target]

IC50: 4.5 nM (AE1 in Trichomonas Vaginalis), 4.5 nM (AE in Ixodes ricinus), 31 nM (AE in Schistosoma mansoni)[1].


[References]

[1]. Götz MG, et al. Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. J Med Chem. 2008 May 8;51(9):2816-32.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H29N5O8

[ Molecular Weight ]:
491.49

[ Storage condition ]:
2-8℃

Related Compounds