(2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6- yl]methylamino]benzoyl]amino]pentanedioic acid

Names

[ Name ]:
(2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6- yl]methylamino]benzoyl]amino]pentanedioic acid

Biological Activity

[Description]:

Levoleucovorin (Levofolinic acid) is the pharmacologically active levoisomer of racemic leucovorin. Levoleucovorin can be used as a rescue agent after high-dose Methotrexate (HY-14519) therapy, and in combination with fluorouracil for the research of advanced metastatic colorectal cancer[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

Human Endogenous Metabolite

[References]

[1]. Chuang VT, et al. Levoleucovorin as replacement for leucovorin in cancer treatment. Ann Pharmacother. 2012 Oct;46(10):1349-57.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₃N₇O₇

[ Molecular Weight ]:
473.43900

[ Exact Mass ]:
473.16600

[ PSA ]:
219.84000

[ LogP ]:
1.15290

Related Compounds

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