CuATSM

Names

[ Name ]:
CuATSM

[Synonym ]:
Copper(2+) (2E,2'E)-2,2'-[(2E,3E)-2,3-butanediylidene]bis(N-methylhydrazinecarbimidothioate)
Hydrazinecarbothioamide, 2,2'-[(1E,2E)-1,2-dimethyl-1,2-ethanediylidene]bis[N-methyl-, copper(2+) salt, (2E,2'E)- (1:1)
ATSM CU-64
0YDK1H9L3A
Cu-ASTM

Biological Activity

[Description]:

CuATSM is a highly potent radical-trapping antioxidant (RTA) and inhibitor of (phospho)lipid peroxidation, thereby accounting for its (their) ability to inhibit ferroptosis.

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Ferroptosis

Research Areas >> Neurological Disease

[References]

[1]. Zilka O, et al. Radical-Trapping Antioxidant Activity of Copper and Nickel Bis(Thiosemicarbazone) Complexes Underlies Their Potency as Inhibitors of Ferroptotic Cell Death. J Am Chem Soc. 2021 Nov 17;143(45):19043-19057.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈H₁₄CuN₆S₂

[ Molecular Weight ]:
321.91

[ Exact Mass ]:
321.001740

[ Appearance of Characters ]:
powder

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: soluble10mg/mL, clear

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Zn II(atsm) is protective in amyotrophic lateral sclerosis model mice via a copper delivery mechanism.

Neurobiol. Dis. 81 , 20-4, (2015)

Mutations in the metalloprotein Cu,Zn-superoxide dismutase (SOD1) cause approximately 20% of familial cases of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease for which effectiv...

Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis.

J. Neurosci. 34(23) , 8021-31, (2014)

Mutations in the metallo-protein Cu/Zn-superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS) in humans and an expression level-dependent phenotype in transgenic rodents. We show that o...

Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis.

Amyotroph. Lateral Scler. Frontotemporal Degener. 14(7-8) , 586-90, (2013)

Our objective was to assess the copper(II) complex of diacetylbis(4-methylthiosemicarbazone) [Cu(II)(atsm)] for its preclinical potential as a novel therapeutic for ALS. Experimental paradigms used we...