10-Oxo Morphine

Names

[ Name ]:
10-Oxo Morphine

[Synonym ]:
10-Oxomorphine
10-Oxomorphine (10-Ketomorphine)
(5a,6a)-7,8-Didehydro-4,5-epoxy-3,6-dihydroxy-17-methylmorphinan-10-on
(5a,6a)-7,8-Didehydro-4,5-epoxy-3,6-dihydroxy-17-methylmorphinan-10-one

Chemical & Physical Properties

[ Density]:
1.53g/cm3

[ Boiling Point ]:
557ºC at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₇NO₄

[ Molecular Weight ]:
299.32100

[ Flash Point ]:
290.6ºC

[ Exact Mass ]:
299.11600

[ PSA ]:
70.00000

[ LogP ]:
0.77620

[ Index of Refraction ]:
1.735

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution

Articles

Impurities in a morphine sulfate drug product identified as 5-(hydroxymethyl)-2-furfural, 10-hydroxymorphine and 10-oxomorphine.

J. Pharm. Sci. 92(3) , 485-93, (2003)

Stability testing of morphine sulfate formulated with nonpareil sugar seeds (consisting of sucrose and starch) and fumaric acid revealed the formation of the three impurities 5-(hydroxymethyl)-2-furfu...

Synthesis and determination of 10-oxomorphine, a decomposition product of morphine.

Pharmazie 39(10) , 687-8, (1984)

10-Oxomorphine, a decomposition product of morphine, was synthesized from 6-O-acetylcodeine, which was oxidized with chromic acid to 6-O-acetyl-10-hydroxycodeine. This substance was then oxidized with...

Related Compounds

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