Roburic Acid

Names

[ Name ]:
Roburic Acid

[Synonym ]:
1-chrysenepropanoic acid, 1,2,3,4,4a,4b,5,6,6a,7,8,9,10,10a,12,12a-hexadecahydro-1,4a,4b,6a,9,10-hexamethyl-2-(1-methylethenyl)-, (1S,2S,4aR,4bS,6aR,9R,10S,10aR,12aR)-
3-[(1S,2S,4aR,4bS,6aR,9R,10S,10aR,12aR)-1,4a,4b,6a,9,10-Hexamethyl-2-(prop-1-en-2-yl)-1,2,3,4,4a,4b,5,6,6a,7,8,9,10,10a,12,12a-hexadecahydrochrysen-1-yl]propanoic acid
Roburinsaeure
3-[(1S,2S,4aR,4bS,6aR,9R,10S,10aR,12aR)-2-Isopropenyl-1,4a,4b,6a,9,10-hexamethyl-1,2,3,4,4a,4b,5,6,6a,7,8,9,10,10a,12,12a-hexadecahydro-1-chrysenyl]propanoic acid
Roburic Acid
Robursaeure

Biological Activity

[Description]:

Roburic acid, a tetracyclic triterpenoid found in Gentiana macrophylla, acts as an inhibitor of COX, with IC50s of 5 and 9 μM for COX-1 and COX-2, respectively[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-1:5 μM (IC50)

COX-2:9 μM (IC50)

[References]

[1]. Cao H, et al. Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation. Pharmacol Res. 2010 Jun;61(6):519-24.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
528.5±49.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₀H₄₈O₂

[ Molecular Weight ]:
440.701

[ Flash Point ]:
424.9±25.0 °C

[ Exact Mass ]:
440.365417

[ PSA ]:
37.30000

[ LogP ]:
11.09

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.532

Safety Information

[ Safety Phrases ]:
24/25

Synthetic Route

Click to get detail synthetic route

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.