BMS 193885

Names

[ Name ]:
BMS 193885

[Synonym ]:
(2S)-2-Hydroxypropanoic acid - dimethyl 4-{3-[({3-[4-(3-methoxyphenyl)piperidin-1-yl]propyl}carbamoyl)amino]phenyl}-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (1:1)
(2S)-2-Hydroxypropanoic acid - dimethyl 4-{3-[({3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl}carbamoyl)amino]phenyl}-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate (1:1)
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-, dimethyl ester, compd. with (2S)-2-hydroxypropanoic acid (1:1)

Biological Activity

[Description]:

BMS-193885 (L-Lactic acid) is a potent, selective, and brain-penetrant neuropeptide Y1 receptor antagonist. BMS-193885 has a Ki value of 3.3 nM for the neuropeptide Y1 receptor, competitively acts on the neuropeptide Y binding site, and can reduce food intake and body weight through central Y1 inhibition[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor

[References]

[1]. Ildiko Antal-Zimanyi, et al. Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y(1) receptor antagonist. Eur J Pharmacol. 2008 Aug 20;590(1-3):224-32.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₆H₄₈N₄O₉

[ Molecular Weight ]:
680.79

[ Exact Mass ]:
680.342102

Related Compounds

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