Insulin-like growth factor II

Insulin-like growth factor II (IGF-2) is the principal somatomedin of human serum. Insulin-like growth factor II exerts permissive and direct effects on neurite outgrowth and enhances survival of sympathetic and sensory neurons[1][2].

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IGF-1R

Research Areas >> Metabolic Disease

Research Areas >> Neurological Disease

Insulin-like growth factor II (IGF-2) (1-100 ng/mL; 24 h) 在 SH-SY5Y 细胞中以剂量依赖的方式显著增加了轴突承载细胞的百分比[2]。 Insulin-like growth factor II (IGF-2) (50 ng/mL; 1-24 h) 和 IGFBP2 联合使用增强了早期 IGF-1R 相关信号[2]。 Western Blot Analysis[2] Cell Line: SH-SY5Y cells Concentration: 50 ng/mL, alone or in combination with 50 ng/mL IGFBP2 Incubation Time: 1, 6, 12, or 24 h Result: Co-treatment increased IGF-1R phosphorylation within 1 h. Increased phosphorylated Akt (s473) within 12 h. Increased production of NF-L after 24 h.

[1]. Daughaday WH, et al. Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. Endocr Rev. 1989 Feb;10(1):68-91.  

[2]. Jeong EY, et al. Enhancement of IGF-2-induced neurite outgrowth by IGF-binding protein-2 and osteoglycin in SH-SY5Y human neuroblastoma cells. Neurosci Lett. 2013 Aug 26;548:249-54.