Hexanoic acid, 6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3, 3a-dihydroxy-3,6, 9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy )azuleno[4,5-b]furan-7-yl ester, [3R-[3.alpha.,3a.

Names

[ Name ]:
Hexanoic acid, 6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3, 3a-dihydroxy-3,6, 9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy )azuleno[4,5-b]furan-7-yl ester, [3R-[3.alpha.,3a.

[Synonym ]:
MFCD00214081

Biological Activity

[Description]:

Thapsigargicin (Thapsigargicine) is a activator of mast cells and leukocytes. Thapsigargicin induces histamine release from rat peritoneal mast cells and human basophil leukocytes. Thapsigargicin increases the cytoplasmic free calcium level in intact human blood platelets[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Ali H, et al. The ability of thapsigargin and thapsigargicin to activate cells involved in the inflammatory response. Br J Pharmacol. 1985 Jul;85(3):705-12.

Chemical & Physical Properties

[ Density]:
1.26g/cm3

[ Boiling Point ]:
673.3ºC at 760 mmHg

[ Molecular Formula ]:
C₃₂H₄₆O₁₂

[ Molecular Weight ]:
622.70

[ Flash Point ]:
203.8ºC

[ Exact Mass ]:
622.29900

[ PSA ]:
171.96000

[ LogP ]:
3.14770

[ Index of Refraction ]:
1.542

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H332

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S26;S36

[ RIDADR ]:
NONH for all modes of transport

Articles

ER stress induces epithelial differentiation in the mouse oesophagus.

Gut 64(2) , 195-202, (2015)

Stress in the endoplasmic reticulum (ER) leads to activation of the unfolded protein response (UPR). Xbp1, a key component of the UPR has recently been linked to the risk of developing oesophageal squ...

Fulfenamic acid sensitive, Ca(2+)-dependent inward current induced by nicotinic acetylcholine receptors in dopamine neurons.

Neurosci. Res. 46(4) , 463-73, (2003)

Nicotinic acetylcholine receptors (nAChRs) exhibit high Ca(2+) permeabilities and the Ca(2+)-influx through the nAChRs may be involved in regulation of a variety of signal processing in the postsynapt...

Cellular calcium deficiency plays a role in neuronal death caused by proteasome inhibitors.

J. Neurochem. 109(5) , 1225-36, (2009)

Cytosolic Ca(2+) concentration ([Ca(2+)](i)) is reduced in cultured neurons undergoing neuronal death caused by inhibitors of the ubiquitin proteasome system. Activation of calcium entry via voltage-g...