Dihydromunduletone
Names
[ CAS No. ]:
674786-20-0
[ Name ]:
Dihydromunduletone
Biological Activity
[Description]:
Dihydromunduletone is a rotenoid derivative that selectively inhibits GPR56 (IC50=21 uM) and GPR114/ADGRG5, but not GPR110 or Class A GPCRs; maximally inhibits GPR56 at 50 uM, also dramatically inhibits GPR114 7TM–stimulated Gs activity; also inhibit the growth of the zebrafish intersegmental vessels.
[References]
References 1. Stoveken HM, et al. Mol Pharmacol. 2016 Sep;90(3):214-24. 2. Wang C, et al. Eur Urol. 2010 Sep;58(3):418-26. View Related Products by Target Other Targets
Chemical & Physical Properties
[ Molecular Formula ]:
C25H28O6
[ Molecular Weight ]:
424.493
Related Compounds
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