N-ω-Acetylhistamine

Names

[ CAS No. ]:
673-49-4

[ Name ]:
N-ω-Acetylhistamine

[Synonym ]:
EINECS 211-610-3
Nomega-Acetylhistamine
N'-Acetylhistamine
N-[2-(1H-imidazol-5-yl)ethyl]acetamide
N-[2-(1H-Imidazol-4-yl)ethyl]acetamide
MFCD00005209
4-(2-acetamidoethyl)imidazole
Nw-acetyl-histamine
Acetylhistamine
N-ω-Acetylhistamine

Biological Activity

[Description]:

N-acetylhistamine is a histamine metabolite. N-acetylhistamine can be used as a potential biomarker of histidine metabolism for anaphylactoid reactions.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Inflammation/Immunology

[In Vitro]

N-acetylhistamine is an important indice for anaphylactoid reactions[1].

[References]

[1]. Xu Y, et al. Metabolomics analysis of anaphylactoid reaction reveals its mechanism in a rat model. Asian Pac J Allergy Immunol. 2017 Dec;35(4):224-232.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.153g/cm3

[ Boiling Point ]:
501.7ºC at 760 mmHg

[ Melting Point ]:
147-149ºC(lit.)

[ Molecular Formula ]:
C₇H₁₁N₃O

[ Molecular Weight ]:
153.18200

[ Flash Point ]:
257.2ºC

[ Exact Mass ]:
153.09000

[ PSA ]:
57.78000

[ LogP ]:
0.47920

[ Index of Refraction ]:
1.533

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933290090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

[Oscillographic polarography of the alkaloid dolicotheline and several related imidazole derivatives].

Farmakol. Toksikol. 44(2) , 220-4, (1981)

Oscillographic polarography in an alkaline medium has shown that the alkaloid N-isovalerylhistamine appears as an expressive wave of the adsorption character in the cathode portion of the curve. This ...

Monooxygenation of N-acetylhistamine mediated by L-ascorbate.

Biochim. Biophys. Acta 991(2) , 377-9, (1989)

In the presence of molecular oxygen and a catalytic amount of copper(II) ion, ascorbate almost completely degraded histamine (approx. 72%). The reaction was shown to occur at the imidazole group but n...

Effects of intracerebroventricular administration of N-acetylhistamine on body temperature in mice.

Methods Find. Exp. Clin. Pharmacol. 16(8) , 575-81, (1994)

The purpose of this study was to examine the effects of intracerebroventricular (i.c.v.) administration of N-acetylhistamine on rectal temperature, histamine level, histidine decarboxylase (HDC) activ...