Kansuinine E

Names

[ Name ]:
Kansuinine E

[Synonym ]:
3-Pyridinecarboxylic acid, (1aR,3S,4S,5S,7R,7aR,8S,9S,10aR,12R,12aS)-5,7,8,10a-tetrakis(acetyloxy)-4-(benzoyloxy)tetradecahydro-2,2,9,12-tetramethyl-6-methylene-11-oxo-2H-cyclopenta[5,6]cyclododec[1,2-b]oxiren-3-yl ester
(1aR,3S,4S,5S,7R,7aR,8S,9S,10aR,12R,12aS)-5,7,8,10a-Tetraacetoxy-4-(benzoyloxy)-2,2,9,12-tetramethyl-6-methylene-11-oxotetradecahydro-1aH-cyclopenta[5,6]cyclododeca[1,2-b]oxiren-3-yl nicotinate

Biological Activity

[Description]:

Kansuinine E is a plant-derived nitric oxide inhibitor (IC50=6.3 μM). Kansuinine E belongs to jatrophane-type diterpenoids and is isolated from the roots of E. kansui[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Target]

IC50: 6.3 μM (nitric oxide)[1].

[References]

[1]. Lee JW, et al. Jatrophane and ingenane-type diterpenoids from Euphorbia kansui inhibit the LPS-induced NO production in RAW 264.7 cells. Bioorg Med Chem Lett. 2016;26(14):3351-3354.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
787.7±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₁H₄₇NO₁₄

[ Molecular Weight ]:
777.810

[ Flash Point ]:
430.2±32.9 °C

[ Exact Mass ]:
777.299683

[ LogP ]:
6.91

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.570

Related Compounds

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