Bay H 2049

Names

[ Name ]:
Bay H 2049

[Synonym ]:
batracyclin
Batracylin
Daniquidona [INN-Spanish]
8-aminoisoindolo<1,2-b>quinazolin-12(10H)-one
Isoindolo(1,2-b)quinazolin-12(10H)-one,8-amino
Daniquidonum [INN-Latin]
Daniquidone

Biological Activity

[Description]:

Batracylin (NSC320846) is a potent DNA Topoisomerases I and DNA Topoisomerases II inhibitor. Batracylin shows cytotoxicity and antiproliferative activity. Batracylin induces DNA breaks[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

[References]

[1]. Rao VA, et al. Batracylin (NSC 320846), a dual inhibitor of DNA topoisomerases I and II induces histone gamma-H2AX as a biomarker of DNA damage. Cancer Res. 2007 Oct 15;67(20):9971-9.

Chemical & Physical Properties

[ Density]:
1.46g/cm3

[ Boiling Point ]:
524ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₁N₃O

[ Molecular Weight ]:
249.27

[ Flash Point ]:
270.7ºC

[ Exact Mass ]:
249.09000

[ PSA ]:
58.69000

[ LogP ]:
2.27120

[ Index of Refraction ]:
1.781

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NR3900000

CHEMICAL NAME :: Isoindolo(1,2-b)quinazolin-12(10H)-one, 8-amino-

CAS REGISTRY NUMBER :: 67199-66-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C15-H11-N3-O

MOLECULAR WEIGHT :: 249.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 1 umol/L

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 126,39,1994

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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