HSDB 3314

Names

[ CAS No. ]:
67-96-9

[ Name ]:
HSDB 3314

[Synonym ]:
Dihydrotachysterin2
AT-10
ANTITANIL
Dygrayl
parterol
MFCD00867069
dygratyl
Tachyrol
DIHYDROTACHYSTEROL
dihydral
dht2
EINECS 200-672-7

Biological Activity

[Description]:

Dihydrotachysterol is a synthetic analog of vitamin D. Dihydrotachysterol can be used to for the research of hypocalcemia (lack of calcium in the blood) and hypoparathyroidism (lack of parathyroid hormone in the body) [1][2].

[Related Catalog]:

Signaling Pathways >> Vitamin D Related >> VD/VDR

Research Areas >> Metabolic Disease

[In Vitro]

Dihydrotachysterol is effective in the elevation of serum calcium by stimulating intestinal calcium absorption and mobilizing bone calcium in the absence of parathyroid hormone and of functioning renal tissue[1]. Dihydrotachysterol also increases renal phosphate excretion[1].

[In Vivo]

Dihydrotachysterol is a potent synthetic vitamin D analogue that is widely available but more expensive than vitamin D2. It has an onset of action and half-life between those of vitamin D2 and calcitriol. Dihydrotachysterol (initially given at 0.03 to 0.08 mg/kg/day for 2 to 3 days. The final dosages range from 0.004 to 0.04 mg/kg/day) is useful for the treatment of hypoparathyroidism[2]. Animal Model: Animal Model: Five young to middle-aged cats of mixed breeding[2] Dosage: Initially given at a dosage ranging from 0.03 to 0.08 mg/kg/day for 2 to 3 days. The final dosage ranged from 0.004 to 0.04 mg/kg/day. Administration: Oral administration Result: Was useful for the treatment of hypoparathyroidism.

[References]

[1]. I Quack, et al. Dihydrotachysterol therapy for hypoparathyroidism: consequences of inadequate monitoring. Five cases and a review. Exp Clin Endocrinol Diabetes. 2005 Jul;113(7):376-80.

[2]. M E Peterson, et al. Idiopathic hypoparathyroidism in five cats. J Vet Intern Med. Jan-Feb 1991;5(1):47-51.

Chemical & Physical Properties

[ Density]:
1.003 g/cm3

[ Boiling Point ]:
499.5ºC at 760 mmHg

[ Melting Point ]:
131ºC

[ Molecular Formula ]:
C₂₈H₄₆O

[ Molecular Weight ]:
398.66400

[ Flash Point ]:
217.6ºC

[ Exact Mass ]:
398.35500

[ PSA ]:
20.23000

[ LogP ]:
7.72090

[ Index of Refraction ]:
1.569

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WW0600000

CHEMICAL NAME :: Tachysterol, dihydro-

CAS REGISTRY NUMBER :: 67-96-9

LAST UPDATED :: 199504

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C28-H46-O

MOLECULAR WEIGHT :: 398.74

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 288 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,330,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 104 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,330,1982 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 150 mg/kg

SEX/DURATION :: female 1-5 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: CUSCAM Current Science. (Current Science Assoc., Sadashivanagar P.O., Bangalore 560 080, India) V.1- 1932- Volume(issue)/page/year: 41,181,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5329 No. of Facilities: 19 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 403 (estimated) No. of Female Employees: 189 (estimated)

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
Missing Phrase - N15.00950417

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
22

[ Safety Phrases ]:
36

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
WW0600000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Synthetic Route

Click to get detail synthetic route

Articles

Prevalence and correction of 25(OH) vitamin D deficiency in peritoneal dialysis patients.

Perit. Dial. Int. 25(4) , 362-6, (2005)

Peritoneal dialysis (PD) patients are at risk for 25(OH) vitamin D deficiency due to effluent loss in addition to traditional risk factors.To measure 25(OH) vitamin D deficiency in prevalent PD patien...

3-nitropropionic acid-induced hydrogen peroxide, mitochondrial DNA damage, and cell death are attenuated by Bcl-2 overexpression in PC12 cells.

Brain Res. Mol. Brain Res. 133(2) , 215-23, (2005)

3-nitropropionic acid (3-NPA), a complex II inhibitor of the electron transport chain, causes Huntington disease-like symptoms after administration into animals. However, primary mechanisms of cell de...

Calpain-mediated AQP2 proteolysis in inner medullary collecting duct.

Biochem. Biophys. Res. Commun. 303(1) , 52-8, (2003)

Vitamin D-elicited hypercalcemia/hypercalciuria is associated with polyuria in humans and in animal models. In rats, dihydrotachysterol (DHT) induces AQP2 water channel downregulation despite unaltere...

Related Compounds

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