AKCI

Names

[ Name ]:
AKCI

[Synonym ]:
2-Quinazolinamine, 4,8-dimethyl-N-[1,4,5,6-tetrahydro-5-[2-(4-morpholinyl)ethyl]-1,3,5-triazin-2-yl]-
4,8-Dimethyl-N-{5-[2-(4-morpholinyl)ethyl]-1,4,5,6-tetrahydro-1,3,5-triazin-2-yl}-2-quinazolinamine
1,3,5-triazin-2-amine, N-[(2E)-4,8-dimethyl-2(1H)-quinazolinylidene]-1,4,5,6-tetrahydro-5-[2-(4-morpholinyl)ethyl]-

Biological Activity

[Description]:

A small-molecule inhibitor that blocks the Aurora C/IκBα interaction (IC50=24.9 uM) and exerts antitumor activity in MDA-MB-231 breast cancer cells; induces G2/M cell-cycle arrest through modulation of the p53/p21/CDC2/cyclin B1 pathways, significantly inhibits MDA-MB-231 cell migration and invasion, as well as decreasing colony formation and tumor growth, decreases PMA-induced activation of NF-κB.

[References]

References 1. Han EH, et al. Oncotarget. 2017 Jun 29;8(41):69691-69708. View Related Products by Target Aurora Kinase

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
555.9±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₇N₇O

[ Molecular Weight ]:
369.464

[ Flash Point ]:
290.0±32.9 °C

[ Exact Mass ]:
369.227722

[ LogP ]:
0.64

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.684

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.