669750-88-3
669750-88-3 structure
- Name: AKCI
- Chemical Name: 4,8-Dimethyl-N-{5-[2-(4-morpholinyl)ethyl]-1,4,5,6-tetrahydro-1,3,5-triazin-2-yl}-2-quinazolinamine
- CAS Number: 669750-88-3
- Molecular Formula: C19H27N7O
- Molecular Weight: 369.464
- Create Date: 2020-01-11 13:33:35
- Modify Date: 2024-03-02 10:41:04
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A small-molecule inhibitor that blocks the Aurora C/IκBα interaction (IC50=24.9 uM) and exerts antitumor activity in MDA-MB-231 breast cancer cells; induces G2/M cell-cycle arrest through modulation of the p53/p21/CDC2/cyclin B1 pathways, significantly inhibits MDA-MB-231 cell migration and invasion, as well as decreasing colony formation and tumor growth, decreases PMA-induced activation of NF-κB.
| Name | 4,8-Dimethyl-N-{5-[2-(4-morpholinyl)ethyl]-1,4,5,6-tetrahydro-1,3,5-triazin-2-yl}-2-quinazolinamine |
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| Synonyms |
2-Quinazolinamine, 4,8-dimethyl-N-[1,4,5,6-tetrahydro-5-[2-(4-morpholinyl)ethyl]-1,3,5-triazin-2-yl]-
4,8-Dimethyl-N-{5-[2-(4-morpholinyl)ethyl]-1,4,5,6-tetrahydro-1,3,5-triazin-2-yl}-2-quinazolinamine 1,3,5-triazin-2-amine, N-[(2E)-4,8-dimethyl-2(1H)-quinazolinylidene]-1,4,5,6-tetrahydro-5-[2-(4-morpholinyl)ethyl]- |
| Description | A small-molecule inhibitor that blocks the Aurora C/IκBα interaction (IC50=24.9 uM) and exerts antitumor activity in MDA-MB-231 breast cancer cells; induces G2/M cell-cycle arrest through modulation of the p53/p21/CDC2/cyclin B1 pathways, significantly inhibits MDA-MB-231 cell migration and invasion, as well as decreasing colony formation and tumor growth, decreases PMA-induced activation of NF-κB. |
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| References | References 1. Han EH, et al. Oncotarget. 2017 Jun 29;8(41):69691-69708. View Related Products by Target Aurora Kinase |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 555.9±60.0 °C at 760 mmHg |
| Molecular Formula | C19H27N7O |
| Molecular Weight | 369.464 |
| Flash Point | 290.0±32.9 °C |
| Exact Mass | 369.227722 |
| LogP | 0.64 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.684 |