(2R)-2-{3-[3-(4-Methoxybenzoyl)-2-methyl-6-(trifluoromethoxy)-1H- indol-1-yl]phenoxy}butanoic acid

Names

[ Name ]:
(2R)-2-{3-[3-(4-Methoxybenzoyl)-2-methyl-6-(trifluoromethoxy)-1H- indol-1-yl]phenoxy}butanoic acid

Biological Activity

[Description]:

MK-0533 is a novel PPARγ partial agonist for the prevention of vascular endothelial dysfunction (VED) and VED-related cardiovascular disease.

[References]

1. Acton JJ 3rd, et al. Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic acid (MK-0533): a novel selective peroxisome proliferator-activated receptor gamma modulator for the treatment of type 2 diabetes mellitus with a reduced potential to increase plasma and extracellular fluid volume. J Med Chem. 2009 Jul 9;52(13):3846-54.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₂₄F₃NO₆

[ Molecular Weight ]:
527.48800

[ Exact Mass ]:
527.15600

[ PSA ]:
86.99000

[ LogP ]:
6.31910