668455-28-5
668455-28-5 structure
- Name: (2R)-2-{3-[3-(4-Methoxybenzoyl)-2-methyl-6-(trifluoromethoxy)-1H- indol-1-yl]phenoxy}butanoic acid
- Chemical Name: (2R)-2-{3-[3-(4-Methoxybenzoyl)-2-methyl-6-(trifluoromethoxy)-1H- indol-1-yl]phenoxy}butanoic acid
- CAS Number: 668455-28-5
- Molecular Formula: C28H24F3NO6
- Molecular Weight: 527.48800
- Create Date: 2016-07-06 14:46:50
- Modify Date: 2024-12-02 14:32:28
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MK-0533 is a novel PPARγ partial agonist for the prevention of vascular endothelial dysfunction (VED) and VED-related cardiovascular disease.
| Name | (2R)-2-{3-[3-(4-Methoxybenzoyl)-2-methyl-6-(trifluoromethoxy)-1H- indol-1-yl]phenoxy}butanoic acid |
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| Description | MK-0533 is a novel PPARγ partial agonist for the prevention of vascular endothelial dysfunction (VED) and VED-related cardiovascular disease. |
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| References | 1. Acton JJ 3rd, et al. Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic acid (MK-0533): a novel selective peroxisome proliferator-activated receptor gamma modulator for the treatment of type 2 diabetes mellitus with a reduced potential to increase plasma and extracellular fluid volume. J Med Chem. 2009 Jul 9;52(13):3846-54. |
| Molecular Formula | C28H24F3NO6 |
|---|---|
| Molecular Weight | 527.48800 |
| Exact Mass | 527.15600 |
| PSA | 86.99000 |
| LogP | 6.31910 |