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Jatrorrhizine Hydrochloride

Names

[ CAS No. ]:
6681-15-8

[ Name ]:
Jatrorrhizine Hydrochloride

[Synonym ]:
Jatorrhizine,chloride
3-Hydroxy-2,9,10-trimethoxy-5,6-dihydro-isochino[3,2-a]isochinolinylium,Chlorid
Jatrorrhizine chloride
3-hydroxy-2,9,10-trimethoxy-5,6-dihydro-isoquino[3,2-a]isoquinolinylium,chloride
JatrorrhizineHydrochloride
Neprotine chloride
Jatrochizine chloride
Jatrorrhizine Hydrochloride

Biological Activity

[Description]:

Jatrorrhizine chloride is a potent and orally active uptake-2 transporter inhibitor, it can be isolated from various Chinese medicinal plants[1]. Jatrorrhizine chloride exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of MAPK pathway in HT22 hippocampal neurons[2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[Target]

Uptake-2 transporter[1]


[In Vitro]

Organic cation transporters (OCTs) and the plasma membrane monoamine transporter (PMAT) are major uptake-2 transporters[1]. Jatrorrhizine chloride significantly inhibits the plasma membrane monoamine transporter (PMAT) -mediated MPP+ uptake in a concentration-dependent manner with an IC50 value of 1.05 μM[1]. Jatrorrhizine chloride demonstrates a more powerful inhibition on serotonin (5-HT) and norepinephrine (NE) uptake mediated by hOCT2 and hOCT3 than that mediated by PMAT[1]. Jatrorrhizine chloride attenuates the H2O2-induced Bcl-2/Bax ratio reduction and caspase-3 activation in these neurons[2].

[References]

[1]. Sun S, et al. Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice. Xenobiotica. 2019 Oct;49(10):1237-1243.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H20ClNO4

[ Molecular Weight ]:
374.83800

[ Exact Mass ]:
374.11600

[ PSA ]:
51.80000

[ LogP ]:
3.88380

Related Compounds

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