<Suppliers Price>

diosbulbin d

Names

[ CAS No. ]:
66756-57-8

[ Name ]:
diosbulbin d

[Synonym ]:
(1S,2S,5S,8S,10R,11R,13S)-8-(3-Furyl)-10-methyl-7,14-dioxatetracyclo[11.2.1.0.0]hexadecane-3,6,15-trione
7,10-Methano-2H-pyrano[4,3-g][3]benzoxepin-4,6,8(1H)-trione, 2-(3-furanyl)octahydro-11b-methyl-, (2S,4aS,6aS,7S,10S,11aR,11bR)-
7,10-Methano-2H-pyrano[4,3-g][3]benzoxepin-4,6,8(1H)-trione, 2-(3-furanyl)octahydro-11b-methyl-
8-(3-Furyl)-10-methyl-7,14-dioxatetracyclo[11.2.1.0.0]hexadecane-3,6,15-trione
diosbulbin-d

Biological Activity

[Description]:

Diosbulbin D is a potential hepatotoxic compound that can be isolated from Dioscorea bulbifera L.. Diosbulbin D induces apoptosis in L-02 cells[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Metabolic Disease

[In Vitro]

Diosbulbin D (10-80 μM; 12-72 h) 可诱导人正常肝脏 L-02 细胞毒性[1]。 Diosbulbin D (40 μM; 24 h) 诱导 L-02 细胞形态改变[1]。 Diosbulbin D (20-80 μM; 12-48 h) 诱导 L-02 细胞凋亡，并呈时间和浓度依赖性[1]。 Diosbulbin D (20-80 μM; 24 h) 诱导 L-02 细胞 caspase 3 的激活[1]。 Cell Viability Assay[1] Cell Line: L-02 cells Concentration: 10, 20, 40 and 80 μM Incubation Time: 12, 24, 48 and 72 h Result: Decreased L-02 cells viability in a concentration- and time-dependent manner. Apoptosis Analysis[1] Cell Line: L-02 cells Concentration: 20, 40 and 80 μM Incubation Time: 12, 24 and 48 h Result: Induced apoptosis in a time- and concentration-dependent manner.

[References]

[1]. Ma M, et al. The furano norclerodane diterpenoid disobulbin-D induces apoptosis in normal human liver L-02 cells. Exp Toxicol Pathol. 2012 Sep;64(6):611-8.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
599.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H20O6

[ Molecular Weight ]:
344.36

[ Flash Point ]:
316.2±30.1 °C

[ Exact Mass ]:
344.125977

[ PSA ]:
82.81000

[ LogP ]:
-0.35

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.556

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds