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1-(3-beta-Azido-2,3-dideoxy-5-O-trityl-beta-D-threopenta-furanosyl)thyMine

Names

[ CAS No. ]:
66503-47-7

[ Name ]:
1-(3-beta-Azido-2,3-dideoxy-5-O-trityl-beta-D-threopenta-furanosyl)thyMine

[Synonym ]:
1-(3-Azido-2,3-dideoxy-5-O-trityl-β-D-threo-pentofuranosyl)thymine
1-(3'-azido-2',3'-dideoxy-5'-O-trityl-β-D-xylofuranosyl)thymine
1-(3-azido-O5-trityl-β-D-threo-2,3-dideoxy-pentofuranosyl)-5-methyl-1H-pyrimidine-2,4-dione

Biological Activity

[Description]:

1-(3-β-Azido-2,3-dideoxy-5-O-trityl-D-threopenta-furanosyl)thymine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C29H27N5O4

[ Molecular Weight ]:
509.56

[ Exact Mass ]:
509.20600

[ PSA ]:
123.07000

[ LogP ]:
4.27286

Precursor & DownStream

Precursor

DownStream