2,3'-Bi-1H-indole,2,3-dihydro-

Names

[ Name ]:
2,3'-Bi-1H-indole,2,3-dihydro-

[Synonym ]:
2,3-dihydro-1H,1'H-[2,3']biindolyl
3-(indolin-2-yl)indole
2,3-dihydro-(1,4)dioxino(2,3-c)pyridin-7-carbaldehyde
2-(3-indolyl)-2,3-dihydroindole
2H,3H-[1,4]dioxino[2,3-c]pyridine-7-carbaldehyde
2,3-Dihydro-<2,3'-biindole>
3-(indolin-2-yl)-1H-indole
2-(3'-indolyl)indoline
2-(indol-3-yl)-2,3-dihydroindole
2,3-dihydro-[1,4]dioxino[2,3-c]pyridine-7-carboxaldehyde
2,3-dihydro[1,4]dioxino[2,3-c]pyridine-7-carbaldehyde

Biological Activity

[Description]:

VPC13163 is a potent androgen receptor (AR) BF3 inhibitor with an IC50 of 0.31 µM. VPC13163 has anticancer effects[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Androgen Receptor

[Target]

IC50: 0.31 µM (AR BF3)[1]

[References]

[1]. Ravi Shashi Nayana Munuganti, et al. Abstract 2508: The development of anti-androgens with a novel mechanism of action for treatment of castration-resistant prostate cancer. Cancer Res (2014) 74 (19_Supplement): 2508.

Chemical & Physical Properties

[ Density]:
1.225g/cm3

[ Boiling Point ]:
449.3ºC at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₄N₂

[ Molecular Weight ]:
234.30

[ Flash Point ]:
225.5ºC

[ Exact Mass ]:
234.11600

[ PSA ]:
27.82000

[ LogP ]:
4.01520

[ Index of Refraction ]:
1.699

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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