Methyl 2-acetamidoacrylate

[ Boiling Point ]:
104 °C8 mm Hg(lit.)

[ Melting Point ]:
50-52 °C(lit.)

[ Molecular Formula ]:
C₆H₉NO₃

[ Molecular Weight ]:
143.14100

[ Flash Point ]:
>230 °F

[ Exact Mass ]:
143.05800

[ PSA ]:
55.40000

[ LogP ]:
0.20010

[ Index of Refraction ]:
1.44

Click to get detail MSDS

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2924199090

Click to get detail synthetic route

Precursor

DownStream

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

The ethyl pyruvate analogues, diethyl oxaloproprionate, 2-acetamidoacrylate, and methyl-2-acetamidoacrylate, exhibit anti-inflammatory properties in vivo and/or in vitro.

Biochem. Pharmacol. 70(11) , 1579-92, (2005)

Ethyl pyruvate (EP) is a simple aliphatic ester derived from the endogenous metabolite, pyruvic acid. EP has been shown to decrease the expression of various pro-inflammatory mediators, including nitr...

Methyl-2-acetamidoacrylate, an ethyl pyruvate analog, decreases sepsis-induced acute kidney injury in mice.

Am. J. Physiol. Renal Physiol. 295(6) , F1825-35, (2008)

We tested the anti-inflammatory agent methyl-2-acetamidoacrylate (M2AA), an ethyl pyruvate analog, in a cecal ligation-and-puncture (CLP) model of sepsis in CD-1 mice. M2AA administration at the time ...

Orthogonal synthesis of indolines and isoquinolines via aryne annulation.

J. Am. Chem. Soc. 130(5) , 1558-9, (2008)

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