rac-AZD 6482

Names

[ Name ]:
rac-AZD 6482

[Synonym ]:
(+/-)-1-tert-Butyldimethylsilyloxy-3-vinylcyclohex-2-ene
2-{[1-(7-methyl-2-morpholin-4-yl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethyl]amino}benzoic acid
3-<(tert-Butyldimethylsilyl)oxy>-1-vinylcyclohexene
Silane,(1,1-dimethylethyl)[(3-ethenyl-2-cyclohexen-1-yl)oxy]dimethyl
(+/-)-2-({1-[7-methyl-2-(morpholin-4-yl)-4-oxo-pyrido[1,2-a]pyrimidin-9-yl]ethyl}amino)benzoic acid
3-(tert-butyldimethylsiloxy)-1-vinyl-1-cyclohexene

Biological Activity

[Description]:

rac-AZD 6482 (rac-KIN-193) is a less active racemate of AZD 6482. AZD 6482 is a potent and selective p110β inhibitor with an IC50 of 0.69 nM.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

Signaling Pathways >> Autophagy >> Autophagy

[References]

[1]. Ni J, et al. Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent. Cancer Discov. 2012 May;2(5):425-33.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₄N₄O₄

[ Molecular Weight ]:
408.45000

[ Exact Mass ]:
408.18000

[ PSA ]:
96.17000

[ LogP ]:
2.84880

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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