6-amino-1,3-dimethyl-5-nitrosouracil

Names

[ Name ]:
6-amino-1,3-dimethyl-5-nitrosouracil

[Synonym ]:
6-amino-1,3-dimethyl-5-nitroso-uracil
1,3-dimethyl-4-amino-5-nitroso-2,6-pyrimidindione
1,3-dimethyl-4-amino-5-nitrosouracil
danu
4-Amino-1,3-dimethyl-5-nitrosouracil
6-amino-5-nitroso-1,3-dimethyluracil
6-amino-1,3-dimethyl-5-nitroso-uraci
6-amino-1,3-dimethyl-5-nitrosopyrimidine 2,4(1H,3H)-dione

Chemical & Physical Properties

[ Density]:
1.408g/cm3

[ Boiling Point ]:
513ºC at 760 mmHg

[ Melting Point ]:
241-243ºC

[ Molecular Formula ]:
C₆H₈N₄O₃

[ Molecular Weight ]:
184.15300

[ Flash Point ]:
264ºC

[ Exact Mass ]:
184.06000

[ PSA ]:
99.45000

[ Index of Refraction ]:
1.63

[ Storage condition ]:
−20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YQ8780000

CHEMICAL NAME :: Uracil, 6-amino-1,3-dimethyl-5-nitroso-

CAS REGISTRY NUMBER :: 6632-68-4

BEILSTEIN REFERENCE NO. :: 0180955

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H8-N4-O3

MOLECULAR WEIGHT :: 184.18

WISWESSER LINE NOTATION :: T6NVNVJ A1 C1 ENO FZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin, Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7. Volume(issue)/page/year: 80,297,1973 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16 gm/kg/34W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

REFERENCE :: ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin, Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7. Volume(issue)/page/year: 80,297,1973

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H351

[ Precautionary Statements ]:
P281

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
40

[ Safety Phrases ]:
22-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
YQ8780000

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%