1H-Imidazol-2-amine, N-(2-bromo-6-fluorophenyl)-4,5-dihydro-, monohydrochloride

Names

[ Name ]:
1H-Imidazol-2-amine, N-(2-bromo-6-fluorophenyl)-4,5-dihydro-, monohydrochloride

[Synonym ]:
N-(2-bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine,hydrochloride

Biological Activity

[Description]:

Romifidine hydrochloride is an α2 adrenergic receptor agonist. Romifidine hydrochloride shows sedation effects in vivo[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Neurological Disease

[In Vivo]

Romifidine hydrochloride (80 μg/kg; i.v. once) produces sedative effects with significantly greater drooping during the 45-90 min time period in welsh mountain ponies[1]. Romifidine hydrochloride (40, 80 and 120 mg/kg; i.v. at seven-day intervals) shows a shallower and shorter-lived sedation than with detomidine in horses[2].

[References]

[1]. England GC, et al. A comparison of the sedative effects of three alpha 2-adrenoceptor agonists (romifidine, detomidine and xylazine) in the horse. J Vet Pharmacol Ther. 1992 Jun;15(2):194-201.

[2]. Hamm D, et al. Sedative and analgesic effects of detomidine and romifidine in horses. Vet Rec. 1995 Apr 1;136(13):324-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₁₀BrClFN₃

[ Molecular Weight ]:
294.55100

[ Exact Mass ]:
292.97300

[ PSA ]:
36.42000

[ LogP ]:
2.59870

Related Compounds

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