Ac-Lys(Ac)-D-Ala-D-lactic acid

Names

[ Name ]:
Ac-Lys(Ac)-D-Ala-D-lactic acid

[Synonym ]:
Nalpha,Nepsilon-Diacetyl-Lys-D-Ala-D-lactic acid
N|A,N|A-Diacetyl-Lys-D-Ala-D-lactic acid
(1R)-1-Carboxyethyl N,N-diacetyl-L-lysyl-D-alaninate
D-Alanine, N,N-diacetyl-L-lysyl-, (1R)-1-carboxyethyl ester
AC-LYS(AC)-D-ALA-D-LACTIC ACID

Biological Activity

[Description]:

Ac-Lys(Ac)-D-Ala-D-Lactic acid is a depsipeptide substrate for penicillin-sensitive D-alanine carboxypeptidases (DD-carboxypeptidases)[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Rasmussen JR, et al. Utilization of a depsipeptide substrate for trapping acyl-enzyme intermediates of penicillin-sensitive D-alanine carboxypeptidases. Proc Natl Acad Sci U S A. 1978 Jan;75(1):84-8.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
740.5±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₂₇N₃O₇

[ Molecular Weight ]:
373.401

[ Flash Point ]:
401.7±32.9 °C

[ Exact Mass ]:
373.184906

[ PSA ]:
150.90000

[ LogP ]:
-1.02

[ Vapour Pressure ]:
0.0±5.3 mmHg at 25°C

[ Index of Refraction ]:
1.495

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2924199090

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Mechanism of penicillin action: penicillin and substrate bind covalently to the same active site serine in two bacterial D-alanine carboxypeptidases.

Proc. Natl. Acad. Sci. U. S. A. 76 , 2730, (1979)

It has been hypothesized that penicillin acts as a structural analog of the acyl-D-alanyl-D-alanine terminus of nascent bacterial cell wall and that it consequently binds to and acylates the active si...

Related Compounds

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