Hainantoxin-IV

Names

[ Name ]:
Hainantoxin-IV

Biological Activity

[Description]:

Hainantoxin-IV is a specific antagonist of Sodium Channel, targeting to tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels. His28 and Lys32 are the key resiudes of Hainantoxin-IV for binding with target, while Hainantoxin-IV adopts an inhibitor cystine knot motif[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Research Areas >> Neurological Disease

[References]

[1]. Liu Y, et al. A positively charged surface patch is important for hainantoxin-IV binding to voltage-gated sodium channels. J Pept Sci. 2012 Oct;18(10):643-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆₆H₂₅₇N₅₃O₅₀S₆

[ Molecular Weight ]:
3987.53

Related Compounds

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