Xanthine oxidoreductase-IN-3

Names

[ Name ]:
Xanthine oxidoreductase-IN-3

[Synonym ]:
Benzamide,N-(4-chlorophenyl)-4-(1H-tetrazol-5-yl)

Biological Activity

[Description]:

Xanthine oxidoreductase-IN-3 is an orally active xanthine oxidoreductase (XOR) inhibitor, with an IC50 of 26.3 nM. Xanthine oxidoreductase-IN-3 can be used for the research of acute hyperuricemia[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase

[Target]

IC50: 26.3 nM (xanthine oxidoreductase)[1]

[In Vivo]

Xanthine oxidoreductase-IN-3 (化合物 IIIa) (5 mg/kg; 口服给药) 在给药后 3 h 显示出降低急性高尿酸血症小鼠尿酸的作用[1]。 Animal Model: ICR mice (18-22 g) were induced acute hyperuricemia by injection of potassium oxonate and hypoxanthine[1] Dosage: 5 mg/kg Administration: Suspended in 0.5% CMC-Na solution for intragastric administration Result: Showed a uric acid-lowering effect from 3 h after administration.

[References]

[1]. Peng W, et, al. Design, synthesis, and evaluation of tricyclic compounds containing phenyl-tetrazole as XOR inhibitors. Eur J Med Chem. 2022 Nov 28;246:114947.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₀ClN₅O

[ Molecular Weight ]:
299.71500

[ Exact Mass ]:
299.05700

[ PSA ]:
87.05000

[ LogP ]:
3.15640

Related Compounds

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