Jedi2

Names

[ Name ]:
Jedi2

[Synonym ]:
hms1431a19

Biological Activity

[Description]:

Jedi2 is a Piezo1 channel activator, but no specific Piezo2 activators. Jedi2 binds to the mouse Piezo1 proteins with a Kd of 2770 μM[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[In Vitro]

Jedi2 evokes Piezo1-mediated Ca2+ influx. Jedi2 (200 μM) specifically elicits dose-dependent responses in mPiezo1-transfected cells, but not in mPiezo2- or vector-transfected cells [1]. Jedi2 (1 mM) causes an increase in Ca2+ in mCherry-positive HEK293T cells transfected with the mPiezo1-mCherry construct, which also responded to Yoda1 (30 μM) [1].

[References]

[1]. Yanfeng Wang, et al. A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel. Nat Commun. 2018 Apr 3;9(1):1300.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₈O₃S

[ Molecular Weight ]:
208.23400

[ Exact Mass ]:
208.01900

[ PSA ]:
78.68000

[ LogP ]:
3.01470

Safety Information

[ Hazard Codes ]:
Xn

Jedi2

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds