Lidamidine hydrochloride
Names
[ CAS No. ]:
65009-35-0
[ Name ]:
Lidamidine hydrochloride
[Synonym ]:
Einecs 265-307-6
LIDAMIDINE(LIDAMIDIUM) HYDROCHLORIDE
Unii-3Q1Q4qjv3v
1-(2,6-Dimethylphenyl)-3-(N-methylcarbamimidoyl)urea hydrochloride (1:1)
Lidamidine hydrochloride
1-(2,6-Dimethylphenyl)-3-methylamidinourea hydrochloride
LIDAMIDINE HCL
Urea, N-(2,6-dimethylphenyl)-N'-[imino(methylamino)methyl]-, hydrochloride (1:1)
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Boiling Point ]:
342.4ºC at 760 mmHg
[ Molecular Formula ]:
C11H17ClN4O
[ Molecular Weight ]:
256.73
[ Flash Point ]:
160.9ºC
[ Exact Mass ]:
256.109100
[ PSA ]:
77.01000
[ LogP ]:
3.33560
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YU4995000
- CHEMICAL NAME :
- Urea, 1-(2,6-xylyl)-3-methylamidino-, hydrochloride
- CAS REGISTRY NUMBER :
- 65009-35-0
- LAST UPDATED :
- 199306
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C11-H16-N4-O.Cl-H
- MOLECULAR WEIGHT :
- 256.77
- WISWESSER LINE NOTATION :
- MUYM1&MVMR B1 F1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 187 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - acute pulmonary edema Kidney, Ureter, Bladder - urine volume increased
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,1471,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 303 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - chromodacryorrhea Behavioral - somnolence (general depressed activity) Kidney, Ureter, Bladder - urine volume increased
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,1471,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 65 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,1471,1978 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 300 mg/kg/30D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition Endocrine - hyperglycemia Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,1471,1978
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 1140 mg/kg/38D-I
- TOXIC EFFECTS :
- Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - death
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,1471,1978